The following athletes were selected “All Conference” by vote of the Western Big 6 Head Boys Basketball Coaches. Coaches nominate athletes from their teams but may not vote for athletes from their own team.
| 2021 Western Big Six Girls Basketball All-Conference Team | ||
| Player | Class | School |
| Breelyn Borum | Sr. | Sterling |
| Brooklyn Borum | Sr. | Sterling |
| Brooklynn Larson | Sr. | Rock Island |
| Kammie Ludwig | Jr. | Geneseo |
| Bralee Trice | Sr. | Moline |
| 2nd Team | ||
| Jade Hunter | Sr. | United Township |
| Riley Jenkins | Sr. | Galesburg |
| Lauren Livingston | Sr. | Galesburg |
| Emily Wilson | Sr. | Quincy |
| Annie Wirth | So. | Geneseo |
| Honorable Mention | ||
| Imari McDuffy | Jr. | Rock Island |
| Ali Rapps | So. | Geneseo |
| Avrie Schmidt | Jr. | Alleman |
| Kadence Tatum | Jr. | Moline |
| 2021 Western Big Six Boys Basketball All-Conference Team | ||
| Player | Class | School |
| 1st Team | ||
| Brock Harding | So. | Moline |
| Eric Price | Sr. | Galesburg |
| Jordan Rice | Sr. | Rock Island |
| Ryne Schimmel | Sr. | Moline |
| Jeremiah Talton | Jr. | Quincy |
| 2nd Team | ||
| Marieon Anderson | Jr. | Rock Island |
| Daslah Geadeyan | Sr. | United Township |
| Amarion Nimmers | Jr. | Rock Island |
| Nate Ottens | Sr. | Sterling |
| Darius Rogers | Jr. | United Township |
| Special Mention | ||
| Demarco Harden | Sr. | Galesburg |
| Mahki Johnson | Jr. | United Township |
| Bristol Lewis | So. | Geneseo |
| Rob Pulliam | Jr. | Moline |
| Colton Sigel | Sr. | Rock Island |
| Kyle Taylor | Jr. | Moline |
| Kyle Traphagen | Sr. | Geneseo |
